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Review Papers | Pharmacology and Toxicology | India | Volume 7 Issue 7, July 2018 | Popularity: 6.4 / 10
Antimicrobial & Anticonvulsant Activity Show Some Newer Phthalimide Derivatives
Deepika Pal
Abstract: The aim of the study was to design, synthesize and investigate the antimicrobial & fungal activity of some N-Phthilimido derivatives of amino acids by Srinivasan et al, 2010. The chemical structures of the titled compound were confirmed by IR, 13CNMR and elemental analysis. All the compounds are screened for antimicrobial activity against gram positive, gram negative bacteria (Escherichia coli, Klebsiella, Staphylococcus epidermitis, Bacillus cereus, Micrococcus leteus, Staphylococcus aureus) and fungal strains (Candida albicans, Aspergillus niger). Synthetic heterocyclic compounds have been found to possess important biological properties including anticonvulsant effects in man and animals. This study was aimed at highlighting the anticonvulsant properties of two phthalimide derivatives (N cyclopentylphthalimide and Nbenzylphthalimide). N-Cyclopentylphthalimide and N-benzylphthalimide were synthesized by Iniaghe et al, 2010 and screened for anticonvulsant properties using adult Swiss mice. Convulsion was induced using maximum electroshock therapy.
Keywords: 13CNMR, Staphylococcus aureus, electroshock therapy, N-Phthilimido derivative
Edition: Volume 7 Issue 7, July 2018
Pages: 161 - 165
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