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Research Paper | Computers in Biology and Medicine | Vietnam | Volume 7 Issue 6, June 2018 | Popularity: 6.3 / 10
Identification of Protein S-Farnesyl Cysteine Prenylation Sites Based on Substrate Specificities
Van-Nui Nguyen, Hai-Minh Nguyen
Abstract: Protein S-farnesyl cysteine prenylation (SFCP) is a specific kind of prenylation involved in the transfer of a farnesyl moiety to a cytoplasmic cysteine at or near the C-terminus of the target protein. It has been exhibited to play very important roles in promoting membrane interactions and biological activities of variety of cellular proteins. With the advancements in proteomic technology recently, the number of experimentally verified SFCP sites is increasing and becomes available. Due to the very important roles caused by S-farnesyl cysteine prenylation, the knowledge insight SFCP is one of the most hot issue nowaday. Howver, the number of proposed models for the identification of SFCP sites has still not met our current demands. Therefore, in this study we are motivated to propose a novel schema for the identification of S-farnesyl cysteine prenylation sites based on substrate specificities
Keywords: Protein prenylation, protein S-farnesyl cysteine prenylation, support vector machine, substrate motif, maximal dependence decomposition
Edition: Volume 7 Issue 6, June 2018
Pages: 758 - 763