Prognostic Benefits of Epithelial Mesenchymal Transition (EMT) markers; Ezrin & Twist-1 Expression in Squamous Cell Carcinoma (SCC) of the Cervix
Abstract: Background The epithelial mesenchymal transition (EMT) process that has been incriminated in cancer metastases has been extensively studied in several cancers. EMT is controlled by several factors and signaling pathways. Studies about these factors are aiming to detect targeted therapy to several cancer types to improve patients' prognosis. Ezrin & Twist-1 were found to have many roles in EMT and cancer metastases in several cancer types but their role in Squamous Cell Carcinoma (SCC) of the cervix has not been clarified yet. Aim of this study is, to evaluate the prognostic roles of Ezrin & Twist-1 tissue protein expression in Squamous Cell Carcinoma (SCC) of the Cervix. Methods we have assessed theEzrin & Twist-1 expression using immunohistochemistry in section from 40 paraffin blocks of 40 patients of SCC of the cervix, we have followed the 40 patients for about 3 years aiming to detect the correlations between tissue protein expression of both markers, clincopathological features and patients prognosis. Results Ezrin expression was positively correlated with increased cancer size, presence of L. N metastases (p=0.003), higher cancer grade (p=0.006), presence of lymphovascular invasion (p=0.004), advanced FIGO stage (p
Keywords: SCC of the cervix, Ezrin, Twist-1, immunohistochemistry, prognosis
How to Cite?: Dina A. Khairy, Abla S. Mahmoud, Amir M. Salem, "Prognostic Benefits of Epithelial Mesenchymal Transition (EMT) markers; Ezrin & Twist-1 Expression in Squamous Cell Carcinoma (SCC) of the Cervix", Volume 7 Issue 5, May 2018, International Journal of Science and Research (IJSR), Pages: 1052-1061, https://www.ijsr.net/getabstract.php?paperid=ART20182782, DOI: https://dx.doi.org/10.21275/ART20182782