Stem Cell Markers Epithelial Cell Adhesion Molecule (EpCAM) & Cluster of Differentiation (CD44) Expression in Colon Cancer Patients in Relation to Prognosis and Survival
Abstract: Background - Worldwide, Colon cancer is the third & the second most common cancer in males & female respectively. Its recurrence, therapy resistance and metastasis remain causes of poor prognosis. The relationship between cancer stem cell (CSC) behavior and chemo-resistance to chemotherapy in patients with colon cancer is a recent point of researches that has taken attention. Identification of CSCs needed specific cell surface markers. CD44 had been the most frequently researched marker for colon CSCs. EpCAM is a cell surface molecule involved in cell to cell adhesion that is expressed in many epithelial carcinomas. Aim of the work - was to evaluate CSC markers EPCAM & CD44 expressions in colon carcinoma correlating their expressions with clinicopathological parameters and patients outcome. Patients and Methods The clinic-pathological correlations between CD44 & EpCAM expressions were assessed in specimens of colon carcinoma embedded in paraffin blocks and were taken from 50 patients, which we followed up for survival and prognosis. Results- CD 44 & EpCam positive expression was significantly correlated with the grade, stage, presence of lymph node, lymphovascular invasion (p
Keywords: Stem cell markers, CD44, EpCam, colon cancer, survival
How to Cite?: Lobna A. Abdelaziz, Ola A. Megahed, Ola A. Harb, Loay M. Gertallah, Ahmed M. Sallam, "Stem Cell Markers Epithelial Cell Adhesion Molecule (EpCAM) & Cluster of Differentiation (CD44) Expression in Colon Cancer Patients in Relation to Prognosis and Survival", Volume 6 Issue 2, February 2017, International Journal of Science and Research (IJSR), Pages: 994-1005, https://www.ijsr.net/getabstract.php?paperid=ART2017780, DOI: https://dx.doi.org/10.21275/ART2017780