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Research Paper | Dental Science | Iraq | Volume 6 Issue 6, June 2017
Assessment of Interleukin-1? and Myeloperoxidase Levels around Implants versus Natural Teeth with the Impact of Aloe Vera
Ahlam T. Mohammed | Nadia Aftan AL-Rawi [2] | Batool Hassan AL-Ghurabi
Abstract: Background It is essential that peri-implant and periodontal sites are studied to contribute comparison data for investigations that are dealing with diseased sites. The objective of this study was to compare the expression of host-derived markers interleukin-1 (IL-1) and myeloperoxidase (MPO) in peri-implant sulcular fluid (PISF) with the gingival crevicular fluid (GCF) of contralateral natural teeth and to investigate the anti-inflammatory effect of Aloe vera gel on these biomarkers. Materials and Methods 20 subjects aged 25- 45 year who have one clinically stable titanium implant carrying a full ceramic crown and one contralateral natural tooth were enrolled in a split-mouth study. Clinical parameters were measured including Plaque index (Pl I), , Gingival Index (GI), Probing depth (PD). PISF and GCF were collected and the levels of interleukin-1 and myeloperoxidase were determined using ELISA technique at baseline and 2 weeks after application of Aloe vera gel. Results IL-1 level in PISF was higher than in GCF with no significant difference (p > 0.05) while MPO concentration was higher in PISF than in GCF with highly significantly difference (P< 0.01). Positive correlations were found between the levels of IL-1 and MPO with clinical parameters (Pl I, GI and PD). After application of Aloe vera gel there was a reduction in the levels of both IL-1 and MPO with no significant difference (p > 0.05) for IL-1 and highly significantly difference (P< 0.01) for MPO in implants group only. ConclusionsDifferential expression of specific biomarkers in GCF versus their levels in PISF is important information prior to establishing PISF as a diagnostic fluid to monitor peri-implant health. Inflammatory mediators production were higher around implants than teeth and Aloe vera gel has anti-inflammatory effect on peri-implant tissue.
Keywords: Peri-implant sulcular fluid, interleukin-1, myeloperoxidase, Aloe vera
Edition: Volume 6 Issue 6, June 2017,
Pages: 1701 - 1705