International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 102 | Views: 369

Informative Article | Immunology | Bulgaria | Volume 5 Issue 9, September 2016 | Popularity: 6.2 / 10


     

HCV Co-Infection Compromising the Effects of c-ART?An Insight from the HIV-Positive Population in Bulgaria

M. Alexandrova, E. Golkocheva-Markova,.Timchev, N. Yancheva, I. Elenkov, I.Alexiev, P. Teoharov, T. Varleva, M. Nikolova


Abstract: Hepatitis C is common in HIV-positive patients and may considerably impact their prognosis. In Bulgaria, 26 % of the HIV+ patients diagnosed between 2010 and 2014 were HCV seropositive, with a very high rate of active co-infections, and multi-risk profile. Immunological and virological parameters (CD4AC, CD4/CD8, HIV viral load) at the time of HIV diagnosis were similar as compared to HIV monoinfection but deteriorated quickly until registration at hospital. Only 52 % of HIV+ patients with active HCV infection were started on c-ART. In the absence of HCV-specific therapy, they were characterised by significantly inferior immune restoration (in terms of CD4 AC and CD4/CD8 increase), and lower rate of sustained HIV virologic response (63 % vs.38 %, p<0.0001). Altogether, HCV co-infection is a significant risk factor for the progress of HIV epidemics in Bulgaria, and requires specific efforts for successful management and treatment of a multi-risk patients group.


Keywords: HIV, Hepatitis C co-infection, c-ART


Edition: Volume 5 Issue 9, September 2016


Pages: 1732 - 1735



Make Sure to Disable the Pop-Up Blocker of Web Browser




Text copied to Clipboard!
M. Alexandrova, E. Golkocheva-Markova,.Timchev, N. Yancheva, I. Elenkov, I.Alexiev, P. Teoharov, T. Varleva, M. Nikolova, "HCV Co-Infection Compromising the Effects of c-ART?An Insight from the HIV-Positive Population in Bulgaria", International Journal of Science and Research (IJSR), Volume 5 Issue 9, September 2016, pp. 1732-1735, https://www.ijsr.net/getabstract.php?paperid=ART20161555

Similar Articles

Downloads: 114

Research Paper, Immunology, Albania, Volume 6 Issue 4, April 2017

Pages: 1718 - 1723

CD4+ Cell Count in the HIV/AIDS-infected People with Pulmonary Complications

Matilda Gjergji, Jul Bushati, Arjan Harxhi, Dhimiter Kraja

Share this Article

Downloads: 115 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Immunology, India, Volume 6 Issue 2, February 2017

Pages: 1063 - 1067

Incidence of Gastrointestinal and Hepatobiliary Symptoms in HIV Patients

Dr. Ashtaputre Mukund D, Dr. Malviya Prashant B, Dr. Shah Malviya Apeksha P.

Share this Article

Downloads: 127

Research Paper, Immunology, Saudi Arabia, Volume 8 Issue 10, October 2019

Pages: 1592 - 1595

Case Report: Disseminated Non Epidemic Kaposi Sarcoma in Non HIV Non Organ Transplant Heterosexual Yemeni Man: A Discussion of Possible Etiology

Rabab Taha, Roaa Al-osaimi, Omar Alhusaini, Mona Al-Fares

Share this Article
Top