Ravish Kumar Chauhan
Abstract: Various ligands possess medicinal properties. The chelating ligands act as more active medicinal agent than non-chelating ligands. Derivatives like oximes, semicarbazones, and hydrazones of benzaldehyde and substituted benzaldehydes have long been prepared and analyzed by chemists for antibacterial, fungicidal, anti-inflammatory and analgesic activities. The ligands which are active against micro-organisms like bacteria, fungi, or virus can act as a tool in medicinal chemistry. In view of these facts here we have undertaken the screening of 2-pyrazinoyl hydrazide and its derivatives with various aromatic and heterocyclic aldehydes against various bacteria. The present paper deals with the action of bacteria, occurrence, their cultivation and culture and their screening using hydrazones derivatives of 2-pyrazinoyl hydrazide with various aromatic and heterocyclic aldehydes such as benzaldehyde, anisaldehyde, 4-hydroxy-3-methoxy benzaldehyde, p- (N, N-diethyl amino) benzaldehyde, cinnamaldehyde, 4-methyl salicyldehyde and 2-furfuraldehyde.
Keywords: Bacteria, Infection, Chelating ligands, Hydrazones, Antibacterial