Vertical irregularities in buildings are very common feature in urban area, large number of vertical irregular buildings exist in modern urban infrastructures. Soft storey building is a multi-story building in which one storey is kept open for the purpose of vehicle parking, shops, commercial purposes etc. This paper deals with the study of seismic response of a building with soft storeys at different level. The study consists the modelling of a G+6 storied irregular RC building. The modeling of the whole building is carried out using the computer program STAAD.Pro V8i software. Parametric studies on displacement, inter storey drift and base shear have been carried out using equivalent static analysis to investigate the influence of these parameter on the seismic behavior of buildings with soft storey. The selected building is analyzed through five models and the comparison of result is carried out.