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Review Papers | Cancer Science | India | Volume 12 Issue 6, June 2023 | Rating: 5 / 10
Warburg Effect and its Role in Cancer Cell Metabolism: A Comprehensive Review
Sri Chakradhar Challagali
Abstract: The Warburg Effect is a well - established phenomenon in cancer cell metabolism, characterized by the preference of cancer cells to utilize glycolysis for energy production even in the presence of oxygen. Cancer cells metabolic adaptation to glycolysis, leading to lactate accumulation, fuels their rapid proliferation to meet increased energy demands. While initially attributed to mitochondrial dysfunction, recent evidence suggests that the Warburg Effect is a regulated metabolic adaptation driven by oncogenic signaling pathways and changes in the tumor microenvironment. This metabolic shift provides cancer cells with several advantages, including enhanced biosynthesis, resistance to cell death, and the ability to thrive in low oxygen conditions. The Warburg Effect has significant implications in cancer therapy, as targeting the altered metabolic pathways holds promise for developing innovative therapeutic approaches. This review is a comprehensive understanding of the underlying mechanisms of the Warburg Effect and its role in cancer cell metabolism is crucial for the development of more effective and targeted treatments against cancer. Further research in this field is necessary to unravel the intricate interplay between metabolic rewiring, tumor biology, and therapeutic responses, ultimately leading to improved outcomes for cancer patients.
Keywords: Warburg Effect; Cell Metabolism; Cancer therapy; Acidosis
Edition: Volume 12 Issue 6, June 2023,
Pages: 500 - 504