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Research Paper | Chemistry | Iraq | Volume 5 Issue 3, March 2016 | Rating: 6.2 / 10
Synthesis, Characterize and Antimicrobial Study of New Chalcones and Pyrazole Derivatives from Progesterone
Nisreen Kais Abood, Hiba Hayder Ibraheem
Abstract: The aim of this work synthesized a new series of chalcones and pyrazole derivatives from the progesterone, the new steroidal synthesized by the claisen-Schmidt condensation reaction, were react progesterone with different aromatic substituted aldehyde in presence sodium hydroxide afforded chalcones derivatives (1-6). Cyclized the chalcone derivatives by reaction with hydrazine hydrate to afforded pyrazole derivatives (7-12). All synthesized compounds were characterized by measurement melting point, FT-IR spectral, Elemental Analysis and some of them by 1H-NMR spectral and Antimicrobials activities.
Keywords: Progesterone, Chalcone, Pyrazole, Antimicrobial, Biological activity
Edition: Volume 5 Issue 3, March 2016,
Pages: 833 - 836