Synthesis, Characterize and Antimicrobial Study of New Chalcones and Pyrazole Derivatives from Progesterone

Nisreen Kais Abood, Hiba Hayder Ibraheem

Abstract: The aim of this work synthesized a new series of chalcones and pyrazole derivatives from the progesterone, the new steroidal synthesized by the claisen-Schmidt condensation reaction, were react progesterone with different aromatic substituted aldehyde in presence sodium hydroxide afforded chalcones derivatives (1-6). Cyclized the chalcone derivatives by reaction with hydrazine hydrate to afforded pyrazole derivatives (7-12). All synthesized compounds were characterized by measurement melting point, FT-IR spectral, Elemental Analysis and some of them by 1H-NMR spectral and Antimicrobials activities.

Keywords: Progesterone, Chalcone, Pyrazole, Antimicrobial, Biological activity