Synthesis, Characterize and Antimicrobial Study of New Chalcones and Pyrazole Derivatives from Progesterone

Nisreen Kais Abood, Hiba Hayder Ibraheem

Abstract: The aim of this work synthesized a new series of chalcones and pyrazole derivatives from the progesterone, the new steroidal synthesized by the claisen-Schmidt condensation reaction, were react progesterone with different aromatic substituted aldehyde in presence sodium hydroxide afforded chalcones derivatives (1-6). Cyclized the chalcone derivatives by reaction with hydrazine hydrate to afforded pyrazole derivatives (7-12). All synthesized compounds were characterized by measurement melting point, FT-IR spectral, Elemental Analysis and some of them by 1H-NMR spectral and Antimicrobials activities.

Keywords: Progesterone, Chalcone, Pyrazole, Antimicrobial, Biological activity

How to Cite?: Nisreen Kais Abood, Hiba Hayder Ibraheem, "Synthesis, Characterize and Antimicrobial Study of New Chalcones and Pyrazole Derivatives from Progesterone", Volume 5 Issue 3, March 2016, International Journal of Science and Research (IJSR), Pages: 833-836, https://www.ijsr.net/getabstract.php?paperid=NOV161838, DOI: https://dx.doi.org/10.21275/NOV161838