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Research Paper | Chemistry | India | Volume 4 Issue 6, June 2015
Effect of Substituent on the Kinetics of Chlorination of Imidazole by Chlorine in Aqueous Medium
Sandhya Walke | Shantaram Bonde | Vijay Dangat [2] | Ranjana Bhadane
Abstract: The kinetics of chlorination of imidazole and its regioisomers, 1-methylimidazole, 2-methylimidazole and 4-methylimidazole by molecular chlorine has been carried out in aqueous medium to study the effect of the methyl substituent at various positions in the imidazole ring on the reactivity of the substrate. The reactions follow second order kinetics and since the reactions are rapid, a special technique- hydrodynamic voltammetry was used. The specific reaction rate has been studied at various temperatures to determine the thermodynamic parameters, energy of activation, entropy change, enthalpy of activation and free energy of activation. The specific reaction rate values have been found in the following order imidazole < 1-methylimidazole < 2-methylimidazole < 4-methylimidazole for their chlorination using molecular chlorine. Stereochemical principles invoked, justified the observed reactivity order for the regioisomers under study. Thus the present work provides the quantitative verification of the relative nucleophilicity of substrates using kinetics as an investigational tool.
Keywords: Chlorination, Imdazole regioisomers, Kinetics, Hydrodynamic voltammetry
Edition: Volume 4 Issue 6, June 2015,
Pages: 2890 - 2894
Similar Articles with Keyword 'Chlorination'
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Research Paper, Chemistry, India, Volume 3 Issue 10, October 2014
Pages: 797 - 801Rapid Kinetics of Chlorination of Regioisomers of Nitrophenol by Molecular Chlorine in Aqueous Medium Using Rotating Platinum Electrode (RPE)
S. L. Bonde | R. P. Bhadane | V. T. Dangat | T. M. Sukul
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Research Paper, Chemistry, India, Volume 4 Issue 8, August 2015
Pages: 217 - 220Quantitative Structure-Activity Assessment of the Regioisomers of Methyl Indole using Hydrodynamic Voltammetry
Parshuram Maske | Vitthal Borkar | Vijay Dangat [2] | Tania Mondal