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Review Papers | Biochemistry Science | Nigeria | Volume 5 Issue 4, April 2016
Updates on Glucose 6-Phosphate Dehydrogenase (G6PD): From Prokaryotes to Human
Arolasafe Gbemisola J. | Ibraheem Omodele [2] | Otohinoyi David A. [2] | Jeje Temitope O.
Abstract: Glucose 6-phosphate dehydrogenase (G6PD) is the rate determining enzyme that catalyzes the first step in pentose phosphate pathway (PPP) which produces NADPH that serves as reducing agent for reductive biosynthetic reactions such as steroids, fatty acids and nucleotides syntheses. Been ubiquitous, it has been found in wide range of organisms, ranging from prokaryotic organisms to even higher animals like human. Numerous G6PD isoenzymes have been isolated, purified and well characterised. However, obtained information such as its kinetic parameters and biological properties have not been judiciously appropriated for biotechnological/medical applications. This review thus concisely showcases G6PD, focusing on some sources where it has been isolated, purified and characterized, physicochemical/biochemical properties, the benefits and adverse effects its evolution may confer, and the possible biotechnological applications/prospects for the enzyme.
Keywords: Anaemia, Haemoglobin, NADPH, Oxidative stress, Pentose Phosphate Pathway PPP, Reactive Oxygen Species ROS
Edition: Volume 5 Issue 4, April 2016,
Pages: 591 - 608
Similar Articles with Keyword 'Haemoglobin'
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Research Paper, Biochemistry Science, India, Volume 5 Issue 6, June 2016
Pages: 2177 - 2182Study of Serum High-Sensitivity C-Reactive Protein, Ferritin and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
Dr. Sushma B Jagannatha | Dr. Shrikant Chandrakar
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Research Paper, Biochemistry Science, India, Volume 5 Issue 10, October 2016
Pages: 1366 - 1369Evaluation of Haemoglobin Level in Anaemic Patients with Periodontitis
Pamella Sylvia Ann Kelasi | Parveen [56]