International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Review Papers | Biochemistry Science | Nigeria | Volume 5 Issue 4, April 2016


Updates on Glucose 6-Phosphate Dehydrogenase (G6PD): From Prokaryotes to Human

Arolasafe Gbemisola J. | Ibraheem Omodele [2] | Otohinoyi David A. [2] | Jeje Temitope O.


Abstract: Glucose 6-phosphate dehydrogenase (G6PD) is the rate determining enzyme that catalyzes the first step in pentose phosphate pathway (PPP) which produces NADPH that serves as reducing agent for reductive biosynthetic reactions such as steroids, fatty acids and nucleotides syntheses. Been ubiquitous, it has been found in wide range of organisms, ranging from prokaryotic organisms to even higher animals like human. Numerous G6PD isoenzymes have been isolated, purified and well characterised. However, obtained information such as its kinetic parameters and biological properties have not been judiciously appropriated for biotechnological/medical applications. This review thus concisely showcases G6PD, focusing on some sources where it has been isolated, purified and characterized, physicochemical/biochemical properties, the benefits and adverse effects its evolution may confer, and the possible biotechnological applications/prospects for the enzyme.


Keywords: Anaemia, Haemoglobin, NADPH, Oxidative stress, Pentose Phosphate Pathway PPP, Reactive Oxygen Species ROS


Edition: Volume 5 Issue 4, April 2016,


Pages: 591 - 608


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How to Cite this Article?

Arolasafe Gbemisola J., Ibraheem Omodele, Otohinoyi David A., Jeje Temitope O., "Updates on Glucose 6-Phosphate Dehydrogenase (G6PD): From Prokaryotes to Human", International Journal of Science and Research (IJSR), Volume 5 Issue 4, April 2016, pp. 591-608, https://www.ijsr.net/get_abstract.php?paper_id=NOV162615



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