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Research Paper | Pathology | Volume 4 Issue 9, September 2015 | Pages: 222 - 225 | India
Efficacy of Fluorescent Method over Conventional ZN Method in Detection of Acid Fast Bacilli among Various Cytomorphological Patterns of Tubercular Lymphadenitis
Abstract: Background Lymphadenopathy is one of the most common extrapulmonary manifestation of Tuberculosis. Early detection and management of extrapulmonary Tuberculosis prevents mortality and morbidity. Hence, the present study on various cytomorphological patterns and also to study the efficacy of fluorescent method over ZN method in detection of acid-fast bacilli in lymphnode aspirates among tubercular lymphadenitis was performed. Methods Among 201 consecutive patients with clinical suspicion of tuberculosis presenting with lymphadenopathy, fine needle aspirations were performed. Smears were prepared from the aspirates and processed for routine cytology, Ziehl Neelsen [ZN] method and fluorescent method. The efficacy of fluorescent method was analyzed using Chi-Square test. Results Out of 201 aspirates, 197 were studied and remaining 4 were excluded from the study due to diagnosis of malignancy in 1.99 % and inadequate aspiration in 0.49 %. Among the 197 aspirates, tubercular lymphadenitis was diagnosed by cytology in 50.76 % (100/197). In 100 cytological diagnosed tubercular lymphadenitis, positive for acid fast bacilli on ZN method was 24 % (24/100). The smear positivity increased to 38 % (38/100) on fluorescent method [p value -
Keywords: Fluorescent method, Cytology, Tuberculosis, Lymphadenitis
How to Cite?: Dr. Chakkirala Nalini Mohan, Dr. Vamseedhar Annam, Dr. Nitin Gangane, "Efficacy of Fluorescent Method over Conventional ZN Method in Detection of Acid Fast Bacilli among Various Cytomorphological Patterns of Tubercular Lymphadenitis", Volume 4 Issue 9, September 2015, International Journal of Science and Research (IJSR), Pages: 222-225, https://www.ijsr.net/getabstract.php?paperid=SUB158001, DOI: https://dx.doi.org/10.21275/SUB158001