International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 105 | Views: 202

Research Paper | Chemistry | India | Volume 4 Issue 6, June 2015 | Rating: 6.2 / 10

Effect of Substituent on the Kinetics of Chlorination of Imidazole by Chlorine in Aqueous Medium

Sandhya Walke | Shantaram Bonde | Vijay Dangat [2] | Ranjana Bhadane

Abstract: The kinetics of chlorination of imidazole and its regioisomers, 1-methylimidazole, 2-methylimidazole and 4-methylimidazole by molecular chlorine has been carried out in aqueous medium to study the effect of the methyl substituent at various positions in the imidazole ring on the reactivity of the substrate. The reactions follow second order kinetics and since the reactions are rapid, a special technique- hydrodynamic voltammetry was used. The specific reaction rate has been studied at various temperatures to determine the thermodynamic parameters, energy of activation, entropy change, enthalpy of activation and free energy of activation. The specific reaction rate values have been found in the following order imidazole < 1-methylimidazole < 2-methylimidazole < 4-methylimidazole for their chlorination using molecular chlorine. Stereochemical principles invoked, justified the observed reactivity order for the regioisomers under study. Thus the present work provides the quantitative verification of the relative nucleophilicity of substrates using kinetics as an investigational tool.

Keywords: Chlorination, Imdazole regioisomers, Kinetics, Hydrodynamic voltammetry

Edition: Volume 4 Issue 6, June 2015,

Pages: 2890 - 2894

How to Download this Article?

Type Your Valid Email Address below to Receive the Article PDF Link

Verification Code will appear in 2 Seconds ... Wait