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Original Research | Cardiology Science | Volume 15 Issue 6, June 2026 | Pages: 1164 - 1169 | India
Angiotensin Receptor Neprilysin Inhibitor Effect on End Diastolic Volumes on 2D Echocardiography
Abstract: Heart failure remains a major public health challenge, with a growing burden driven by population aging and increasing survival of patients with cardiovascular disease. Sacubitril/ Valsartan, an angiotensin receptor neprilysin inhibitor, has shown clinical benefits in patients with heart failure with reduced ejection fraction, yet evidence regarding sex related differences in cardiac remodeling remains limited. This prospective, randomized, open label study with blinded end point assessment enrolled 310 patients with chronic heart failure in an equal male to female ratio and evaluated changes in left ventricular mass, Tei index, clinical outcomes, and safety over 6 months of therapy. Echocardiographic assessment demonstrated demonstrated a marked reduction in left ventricular mass and significant improvement in Tei index in both groups. After adjustment for baseline for baseline left ventricular mass and treatment, regression of left ventricular mass was greater in males than in females, while improvements in Tei index were comparable between sexes. Rates of mortality, heart failure hospitalization, hypotension, renaldysfunction, and angioedemadid not differ significantly between groups. These findings support the value of serial echocardiographic evaluationof left ventricular mass and Tei INDEX as practical measures of treatment response in patients receiving Sacubitril/Valsartan andhighlight the presence of sex related response in patients receiving Sacubitril/Valsartan and highlight the presence of sex related differences in cardiac structural remodeling during therapy.
Keywords: Heart Failure, Sacubitril Valsartan, Left Ventricular Mass, Tei Index, Sex Differences
How to Cite?: Ashish Kumar D.M., "Angiotensin Receptor Neprilysin Inhibitor Effect on End Diastolic Volumes on 2D Echocardiography", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 1164-1169, https://www.ijsr.net/getabstract.php?paperid=SR26621222545, DOI: https://dx.doi.org/10.21275/SR26621222545