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Original Research | Cardiology Science | Volume 15 Issue 6, June 2026 | Pages: 996 - 1001 | India
Role of Fibrinogen, Albumin and Fibrinogen to Albumin Ratio in Determining Angiographic Severity and Outcomes in Acute Coronary Syndrome in Young Males
Abstract: Background: Acute Coronary Syndrome (ACS) is one of the most important causes of cardiovascular morbidity and mortality. Although coronary artery disease is generally considered a disease of older age groups, the incidence in younger populations is increasing. Early identification of disease severity and prognosis remains crucial for timely intervention. Inflammatory biomarkers have emerged as important predictors of coronary artery disease severity. Fibrinogen, being an acute-phase reactant and pro-thrombotic factor, plays a significant role in plaque instability and thrombosis. Albumin, on the other hand, has anti-inflammatory and antioxidant properties. The fibrinogen-to-albumin ratio (FAR) combines these opposing biomarkers and may serve as a stronger predictor. Materials and Methods: This prospective observational study included 50 young male patients diagnosed with acute coronary syndrome. Clinical evaluation, ECG, echocardiography, and coronary angiography were performed. Serum fibrinogen and albumin levels were measured at admission, and FAR were calculated. Patients were categorized according to angiographic severity and clinical outcomes. Results: The mean age was 32.24 years. Stable angina (44%) and STEMI (34%) were the most common diagnoses. Severe angiographic disease was observed in 52% of patients. Mortality occurred in 16%. Mean fibrinogen levels increased progressively with severity, while albumin levels decreased. FAR showed strong positive correlation with angiographic severity and mortality. ROC analysis demonstrated FAR to have the highest predictive value (AUC 0.89). Conclusion: FAR is an inexpensive, simple, and effective biomarker that correlates significantly with disease severity and short-term outcomes in young male ACS patients.
Keywords: ACS, Fibrinogen, Albumin, FAR, Biomarkers, Coronary Angiography
How to Cite?: Dr. Aditya Anup Bahekar, Dr. Prashant Prabhakar Udgire, Dr Amruta Rajendra Shinde, "Role of Fibrinogen, Albumin and Fibrinogen to Albumin Ratio in Determining Angiographic Severity and Outcomes in Acute Coronary Syndrome in Young Males", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 996-1001, https://www.ijsr.net/getabstract.php?paperid=SR26618202338, DOI: https://dx.doi.org/10.21275/SR26618202338