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Case Series | Oncology Science | Volume 15 Issue 6, June 2026 | Pages: 929 - 934 | India
Verrucous Carcinoma of the Buccal Mucosa: Resection and Reconstruction Using Amniotic Membrane - A Case Series of Three Patients with Favorable Aesthetic and Functional Outcomes
Abstract: Background: Verrucous carcinoma (VC) of the oral cavity is a low-grade, well-differentiated variant of squamous cell carcinoma with distinct exophytic, warty morphology. It predominantly affects the buccal mucosa, often arising in patients with a long-standing history of tobacco and areca nut chewing. Despite its locally aggressive behavior, VC carries a favorable prognosis when managed with adequate surgical excision. Reconstruction of the resultant intraoral defect, particularly in elderly patients, poses a significant challenge; the ideal reconstructive material should be readily available, biocompatible, and promote mucosal healing with minimal morbidity. Methods and Patients: We present a case series of three patients (age range 54-72 years) with biopsy-confirmed verrucous lesions of the buccal mucosa. All three underwent wide local excision under general anesthesia followed by reconstruction using a combination of the pedicled buccal fat pad (BFP) and human amniotic membrane (HAM). Functional outcomes (mouth-opening, mastication, speech) and aesthetic outcomes (contour symmetry, scar visibility) were assessed at one week, one month, and three months post-operatively. Results: All three patients demonstrated uncomplicated wound healing, satisfactory restoration of buccal contour, and preserved oral function at follow-up. No recurrence was observed within the follow-up period. The BFP provided well-vascularized soft-tissue volume replacement, while the HAM acted as a biologic scaffold promoting re-epithelialization and minimizing scar contracture. Conclusion: Wide local excision followed by dual-layer reconstruction with BFP and HAM is a safe, effective, and reproducible technique for managing moderate-sized verrucous lesions of the buccal mucosa, offering excellent aesthetic and functional outcomes.
Keywords: Verrucous carcinoma, buccal mucosa, wide local excision, buccal fat pad, amniotic membrane, oral reconstruction, tobacco, areca nut, oral potentially malignant disorder
How to Cite?: Dr. Omprakash Katnalli, Dr. Aishwarya More, Dr. Sindhoora Nellikar, "Verrucous Carcinoma of the Buccal Mucosa: Resection and Reconstruction Using Amniotic Membrane - A Case Series of Three Patients with Favorable Aesthetic and Functional Outcomes", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 929-934, https://www.ijsr.net/getabstract.php?paperid=SR26615174924, DOI: https://dx.doi.org/10.21275/SR26615174924