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Comparative Study | Medicine | Volume 15 Issue 5, May 2026 | Pages: 773 - 774 | India
Comorbidities As Risk Modifiers in Cerebral Malaria: An Observational Study
Abstract: Malaria remains a major public health problem in tropical and subtropical regions, with Plasmodium falciparum being the most virulent species. Cerebral malaria is a severe and life-threatening complication characterized by altered sensorium, seizures, and coma. Despite advances in antimalarial therapy, cerebral malaria continues to be associated with high morbidity and mortality. The pathophysiology involves sequestration of parasitized red blood cells in cerebral microvasculature, leading to inflammation, hypoxia, and neuronal dysfunction. Clinical outcomes in cerebral malaria vary widely among patients. Underlying comorbidities such as diabetes mellitus, chronic kidney disease, anemia, malnutrition, and chronic liver disease can impair immune response, metabolic stability, organ reserve, that can worsening outcomes in cerebral malaria. Hence, this study was undertaken to assess the role of comorbidities in modifying the clinical course and outcome of cerebral malaria.
Keywords: Cerebral malaria, comorbidities, clinical outcomes, mortality, complications, disease severity, Glasgow Coma Scale (GCS)
How to Cite?: Dr. C. Sai Ravindra Reddy, Dr. Prashant Purkar, "Comorbidities As Risk Modifiers in Cerebral Malaria: An Observational Study", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 773-774, https://www.ijsr.net/getabstract.php?paperid=SR26511155106, DOI: https://dx.dx.doi.org/10.21275/SR26511155106