Hyperuricemia as a Prognostic Marker for Severity of Illness in Sepsis

Dr. Ajit Kumar Shadani, Dr. Deepak Jaiswal

Abstract: This was a prospective observational study conducted at shri Balaji institute of medical sciences with 100 ICU patients with diagnosis of Sepsis based on qSOFA score. Primary end point was to study association of hyperuricemia with mortality. Secondary end point was to study morbidity considering AKI, ARDS and duration of stay in the ICU.Once the patient met the inclusion criteria, consent was obtained and they were interviewed for demographic data such as age and sex, history of other comorbid conditions along with presenting complaints. Patients were subjected to physical examination. Blood samples obtained for uric acid, urea, creatinine, complete blood count, serum electrolytes, ABG and chest X-ray were done. Qualitative data was expressed in frequencies and percentages and Quantitative data in mean and standard deviation. Parametric tests include unpaired t test for intergroup comparison was used. Receiver operative curve (ROC) analysis was done to predict the cut off value of Uric acid to predict outcome. Sensitivity and specificity were calculated based on cut off values. Bar diagrams and pie chart were used to represent the data. p value of <0.05 was considered statistically significant. Results showed that 41% of sepsis patients presented with hyperuricemia (uric acid >6.8 mg/dl). Majority of hyperuricemia patients were between 51-70 years old, with notable male predominance. Hyperuricemia was significantly associated with comorbidities like coronary artery disease, stroke, liver disease, metabolic syndrome, and diabetes with Malignancy. Hyperuricemia was significantly linked to the development of Acute Kidney Injury (AKI), there was no statistically significant association was found with Acute Respiratory Distress Syndrome (ARDS), although a trend was observed. Hyperuricemia was significantly associated with prolonged ICU stays. Hyperuricemia significantly increased mortality risk, Out of 41% of hyperuricemia patients, 23 succumbing to complications, supporting its role as a strong predictor of mortality in sepsis. This research confirms the importance of uric acid as a prognostic biomarker in Sepsis. Elevated uric acid levels are associated with worse outcomes, including Prolonged ICU stays, increased risk of AKI, and higher mortality.

Keywords: SIRS: Systemic Inflammatory Response Syndrome, CAD: Coronary Artery Disease AKI: Acute Kidney Injury, ARDS: Acute Respiratory Distress Syndrome,ICU: Intensive Care Unit, SOFA: Sequential Organ Failure Assessment MAP: Mean Arterial Pressure, WHO: World Health Organization,GBD; Global Burden of Diseases SE: Septic Encephalopathy, APACHE: Acute Physiology And Chronic Health Evaluation SAPS: Simplified Acute Physiology Score ,TISS: Therapeutic Intervention Scoring System LODS: Logistic Organ Dysfunction Score, MODS: Multiple Organ Dysfunction Score MEWS: Modified Early Warning Score,PRESEP: Prehospital Early Sepsis, PS: Acute Physiology Scorings: Glasgow Coma Scale, QSOFA: Quick Sequential Organ Failure Assessment ,EWS: Early ,Warning Score

How to Cite?: Dr. Ajit Kumar Shadani, Dr. Deepak Jaiswal, "Hyperuricemia as a Prognostic Marker for Severity of Illness in Sepsis", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 359-365, https://www.ijsr.net/getabstract.php?paperid=SR26506075959, DOI: https://dx.dx.doi.org/10.21275/SR26506075959

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