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Original Article | Obstetrics and Gynecology | Volume 15 Issue 3, March 2026 | Pages: 1230 - 1234 | India
Predictors & Perinatal Feto-Maternal Outcomes Among Pregnant Women with Pre-Labor Rupture of Membrane: A Hospital-Based Cross-Sectional Study
Abstract: Background: Pre-labor rupture of membranes (PROM) is a significant obstetric complication associated with increased maternal and neonatal morbidity. Reliable admission predictors are essential for early risk stratification. Objectives: To determine predictors and feto-maternal outcomes in pregnancies complicated by PROM, assess incidence of PROM, evaluate maternal complications, analyse neonatal outcome, identify clinical and biochemical factors contributing to adverse outcomes. Methods: A hospital-based cross-sectional study was conducted at the Department of Obstetrics & Gynaecology, Santosh Medical College and Hospital, Ghaziabad. One hundred antenatal women (28-40 weeks gestation) with singleton pregnancy presenting with PROM were enrolled. Demographic, obstetric, biochemical (CRP, TLC), and neonatal data were recorded and analysed. Results: Most women had term PROM (85%) and rupture duration of 12-24 hours (56%). LSCS rate was 56%. Elevated CRP (≥6 mg/L) was significantly associated with chorioamnionitis, febrile morbidity, postpartum complications, low APGAR scores, increased NICU admission, and neonatal infection. Meconium-stained liquor (MSL) was present in 63% and was linked with higher neonatal morbidity. On multivariable logistic regression, prolonged rupture duration (>24 h: aOR 5.93), elevated CRP ≥6 mg/L (aOR 5.21), and MSL (aOR 3.07) independently predicted adverse outcomes. Conclusion: Admission CRP, duration of membrane rupture, and liquor character are practical and independent predictors of adverse feto-maternal outcomes in PROM. Early identification of these factors can guide timely intervention and improve perinatal outcomes.
Keywords: Pre-labor rupture of membranes (PROM), C-reactive protein (CRP), feto-maternal outcomes, meconium-stained liquor, chorioamnionitis, neonatal morbidity, LSCS
How to Cite?: Dr. Shaba Naz Rehman, Dr Alpana Agrawal, Dr Manisha Gupta, "Predictors & Perinatal Feto-Maternal Outcomes Among Pregnant Women with Pre-Labor Rupture of Membrane: A Hospital-Based Cross-Sectional Study", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1230-1234, https://www.ijsr.net/getabstract.php?paperid=SR26317172055, DOI: https://dx.doi.org/10.21275/SR26317172055