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Doctoral Thesis | Gynaecology | Volume 15 Issue 3, March 2026 | Pages: 1001 - 1003 | India
Correlation of Levels of Serum C-Reactive Protein in Pregnancy with Fetomaternal Outcome
Abstract: Background: Maternal systemic inflammation is recognized as a pivotal determinant in the progression and outcome of pregnancy. C-reactive protein (CRP), a pentameric acute-phase reactant synthesized primarily by hepatic parenchyma, serves as a sensitive biomarker for inflammatory activity. The immunological environment of pregnancy requires a delicate equilibrium between fetal tolerance and maternal protection. Disturbances in this balance through exaggerated inflammatory cascades can lead to significant maternal and neonatal complications. Objectives: The primary aim of this study was to meticulously evaluate the association between maternal serum CRP levels during the third trimester and specific fetomaternal outcomes, including premature rupture of membranes (PROM), maternal infection, and neonatal morbidity markers such as Apgar scores and NICU admissions. Methodology: A prospective observational study was conducted at a tertiary care facility involving 255 pregnant women beyond 34 weeks of gestation. Maternal serum CRP was quantified via immunoturbidimetric assay, using a clinical threshold of 10 mg/L to define elevated levels. Statistical analysis was performed using SPSS version 25.0. Results: The study identified that elevated CRP (>10 mg/L) was significantly associated with adverse clinical sequelae. Specifically, the incidence of PROM was drastically higher in the elevated CRP group (60.0%) compared to the normal group (8.3%). Furthermore, neonatal outcomes such as NICU admission rates were markedly increased in the high-CRP cohort (24.0% vs 5.5%). Conclusion: Third-trimester serum CRP estimation provides a robust, cost-effective tool for identifying high-risk pregnancies, enabling timely intervention to mitigate adverse fetomaternal outcomes.
Keywords: C-Reactive Protein, PROM, Neonatal Morbidity, Maternal Sepsis, NICU
How to Cite?: Dr. Geda Hyndavi, Dr. Alpana Agrawal, Dr. Manisha Gupta, Dr. Devika Mor, "Correlation of Levels of Serum C-Reactive Protein in Pregnancy with Fetomaternal Outcome", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1001-1003, https://www.ijsr.net/getabstract.php?paperid=SR26316205204, DOI: https://dx.dx.doi.org/10.21275/SR26316205204