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Analysis Study Research Paper | Pathology | Volume 15 Issue 3, March 2026 | Pages: 1188 - 1193 | India
Audit of Hemoglobin Electrophoresis by HPLC Method and its Correlation with CBC Findings in Tertiary Health Care Centre
Abstract: Background: Hemoglobinopathies are among the most prevalent inherited disorders, especially in the Indian subcontinent. Accurate diagnosis is essential for effective management. While conventional hemoglobin electrophoresis has been widely used, High-Performance Liquid Chromatography (HPLC) offers superior diagnostic precision. The utility of Complete Blood Count (CBC) parameters alongside HPLC may further enhance diagnostic accuracy. Methods: This retrospective observational audit included 200 patients who underwent both HPLC and CBC testing between July and December 2024. Hemoglobin variants were detected using HPLC, and CBC indices including hemoglobin, MCV, MCH, MCHC, and RDW were recorded. The Mentzer Index was calculated for relevant cases. Data analysis was performed using SPSS v25, and correlations were evaluated using Pearson?s or Spearman?s test with p
Keywords: High-Performance Liquid Chromatography, Beta-Thalassemia Trait, Mentzer Index
How to Cite?: Dr. Shloka Deshpande, Dr. Reeta Kataaruka, Dr. C. P. Bhale, "Audit of Hemoglobin Electrophoresis by HPLC Method and its Correlation with CBC Findings in Tertiary Health Care Centre", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1188-1193, https://www.ijsr.net/getabstract.php?paperid=SR26314105740, DOI: https://dx.doi.org/10.21275/SR26314105740