Cu-Naringenin Complex Structural Understanding Pharmacological Uses and Electrochemical Behaviour: A Review

Akshay Kumar, Rakesh Choure

Abstract: Naringenin, a flavonoid with potent anti- inflammatory, anti-cancer, and antioxidant properties, is found naturally in citrus fruits. However, its therapeutic efficacy is limited by its poor bioavailability and solubility. To enhance its pharmacological potential, a naringenin-copper complex was prepared and investigated using FTIR, cyclic voltammetry, and UV-Vis (spectroscopic) techniques. The spectral data confirmed that the copper ion coordinated with the hydroxyl and carbonyl groups of naringenin. The complex Demonstrated enhanced redox stability, antioxidant capacity, and biological activity when compared to the free ligand. While antimicrobial and cytotoxic studies showed superior pharmacological action, antioxidant assays like DPPH and FRAP showed a higher capacity to scavenge radicals. These findings demonstrate that complexation with copper significantly improves the physicochemical and biological properties of Naringenin, suggesting potential therapeutic application.

Keywords: Naringenin-Cu complex, Antioxidant Activity, flavonoids, cyclic voltammetry, spectroscopic characterization, redox stability

How to Cite?: Akshay Kumar, Rakesh Choure, "Cu-Naringenin Complex Structural Understanding Pharmacological Uses and Electrochemical Behaviour: A Review", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 801-805, https://www.ijsr.net/getabstract.php?paperid=SR26312124944, DOI: https://dx.doi.org/10.21275/SR26312124944

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