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Research Proposals or Synopsis | Medical Science | Volume 15 Issue 3, March 2026 | Pages: 1512 - 1514 | India
In Vitro Evaluation of Antihypertensive Potential of Cynanchum acidum (Roxb.) - An Ayurvedic and Experimental Study
Abstract: Hypertension continues to burden public health, often managed through long-term drug therapy that brings its own limitations. Classical Ayurvedic texts describe clinical patterns that resemble elevated blood pressure, linking them to disturbances of V?ta and Pitta, as well as vitiation of Rakta and obstruction of channels. Cynanchum acidum, a plant cited in traditional practice for circulatory and inflammatory conditions, has not been adequately examined in controlled laboratory settings for this purpose. The present work outlines an in vitro experimental design to assess the antihypertensive potential of the compound through phytochemical profiling, angiotensin-converting enzyme inhibition, and antioxidant assays. Hydroalcoholic extracts are subjected to standard screening procedures, and their activity is compared with established references under statistical evaluation. By placing biochemical findings alongside Ayurvedic pharmacodynamics attributes, the study seeks to bridge traditional reasoning with contemporary mechanisms, such as modulation of the renin-angiotensin system and oxidative stress pathways. The anticipated observations may provide preliminary scientific support for the plant's classical indications and enable further in vivo validation and clinical exploration.
Keywords: Hypertension, Cynanchum acidum, ACE inhibition, Antioxidant activity, Hydro alcoholic extract, In-vivo validation
How to Cite?: Dr. Amirthesh K., Dr. Priya Chandrakumari, Dr. Anupam Patel, "In Vitro Evaluation of Antihypertensive Potential of Cynanchum acidum (Roxb.) - An Ayurvedic and Experimental Study", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1512-1514, https://www.ijsr.net/getabstract.php?paperid=SR26306143556, DOI: https://dx.dx.doi.org/10.21275/SR26306143556