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Comparative Studies | Anaesthesiology | Volume 15 Issue 2, February 2026 | Pages: 1479 - 1483 | India
A Comparative Study of Thiamine and Hydrocortisone vs. Hydrocortisone Alone in Improving Hemodynamics, Recovery and Prognosis in Septic Shock Patients in the ICU
Abstract: Background: Hemodynamic instability and a delayed recovery are common outcomes of septic shock, a serious illness with a high morbidity and fatality rate. Conventional treatment plans emphasize early antibiotics, fluid resuscitation, and vasopressors; hydrocortisone is frequently administered because of its anti-inflammatory effects and potential to restore vascular tone in refractory shock. Thiamine (vitamin B1) deficiency is also common in critically ill patients and can worsen mitochondrial dysfunction and hyperlactatemia. Intravenous thiamine supplementation may improve lactate clearance, vasopressor responsiveness, and overall recovery. Objective: With an emphasis on hemodynamic stability, recovery durations, and prognosis, this study compares the effects of combined thiamine and hydrocortisone therapy against hydrocortisone alone in patients with septic shock. Method: In a tertiary intensive care unit, a prospective, randomized, controlled trial was carried out. Twenty patients with septic shock were randomly assigned equally to one of two groups: Group B received hydrocortisone alone, while Group A received thiamine and hydrocortisone together. Vasopressor needs, duration to extubation, length of stay in the intensive care unit, mean arterial pressure (MAP), and overall survival rates were important outcomes. Serum lactate trends and organ dysfunction parameters were closely observed and contrasted. Result: According to preliminary results, the group treated with hydrocortisone plus thiamine showed improved hemodynamic stability, required lower vasopressor doses, and experienced earlier extubation than the group treated with hydrocortisone alone. Additionally, Group A patients had trends toward shorter ICU stays and lower mortality. Conclusion: Better hemodynamics, earlier recovery, and a trend toward improved prognosis were observed with the addition of thiamine to hydrocortisone in patients with septic shock. These findings support thiamine as a promising, low-cost adjunct in septic shock management and justify larger studies to confirm benefit and identify responders.
Keywords: Septic shock, thiamine therapy, hydrocortisone treatment, hemodynamic stability, intensive care recovery
How to Cite?: Dr. Animesh Pratap Singh, Dr. Jessy Vennel, "A Comparative Study of Thiamine and Hydrocortisone vs. Hydrocortisone Alone in Improving Hemodynamics, Recovery and Prognosis in Septic Shock Patients in the ICU", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1479-1483, https://www.ijsr.net/getabstract.php?paperid=SR26225002645, DOI: https://dx.dx.doi.org/10.21275/SR26225002645