Platelets as Endogenous Cellular Adaptogens: A Review of Stress Signaling and Regenerative Implications
Abstract: This review examines platelets as multifunctional regulators of stress adaptation, extending their role beyond hemostasis to include immune modulation, metabolic coordination, and tissue repair. Drawing on literature from stress physiology, platelet signaling, and regenerative medicine, the paper proposes that platelets exhibit key characteristics of adaptogenic systems, including bidirectional regulation and context-dependent signaling across alarm, resistance, and exhaustion phases of stress. Evidence from platelet biology and emerging clinical studies of platelet-rich plasma is discussed in relation to chronic inflammatory and exhaustion-associated conditions. The analysis highlights mechanistic pathways through which platelets influence homeostasis and regenerative responses and considers their therapeutic relevance in environments where conventional regenerative approaches may be constrained. Together, the review presents a unified perspective on platelet-mediated stress adaptation and its implications for systemic regenerative strategies.
Keywords: Platelet signaling, Stress adaptation, Regenerative medicine, Platelet-rich plasma, Cellular resilience
How to Cite?: Tapley Holland, "Platelets as Endogenous Cellular Adaptogens: A Review of Stress Signaling and Regenerative Implications", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1194-1205, https://www.ijsr.net/getabstract.php?paperid=SR26217161231, DOI: https://dx.doi.org/10.21275/SR26217161231