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Case Studies | Neurology | Volume 15 Issue 2, February 2026 | Pages: 992 - 993 | Guyana
Harlequin Syndrome in Guyana: A Case Study and Review
Abstract: Harlequin syndrome is a rare autonomic disorder caused by disruption of sympathetic pathways supplying the face. This results in one-sided facial flushing and sweating, with opposite-side pallor and dryness. Although usually benign, it may indicate underlying pathology and cause psychosocial distress. We report the case of a 41-year-old Indigenous woman with a six-year history of well-defined episodes of facial flushing and sweating on one side, triggered by heat, activity, or emotional stress. Neurological examination was otherwise normal. Magnetic resonance imaging of the brain and cervical and thoracic spine revealed no abnormalities. In the absence of an identifiable cause, a diagnosis of idiopathic Harlequin syndrome was made. The patient was managed conservatively with reassurance, counseling, and trigger avoidance. This is the first known report of Harlequin syndrome in Guyana. It highlights the need to recognize this rare but usually harmless condition.
Keywords: Harlequin syndrome, autonomic dysfunction, hemifacial flushing, anhidrosis, dysautonomia, Guyana
How to Cite?: Sheneka A. Ghent, Jarrel Watson, "Harlequin Syndrome in Guyana: A Case Study and Review", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 992-993, https://www.ijsr.net/getabstract.php?paperid=SR26212171233, DOI: https://dx.dx.doi.org/10.21275/SR26212171233