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Research Paper | Nanotechnology | Volume 15 Issue 5, May 2026 | Pages: 60 - 68 | India
Development and Assessment of Nanoparticles: A Clarithromycin Niosomal Gel for Atopic Dermatitis
Abstract: Atopic dermatitis (AD), also called atopic eczema, is a persistent inflammatory skin condition characterized by eczematous dermatitis, irritated, itchy skin, breakdown of the epidermal barrier, activation of t-cells, and imbalance in the microbiome. AD affects 2.1 to 4.1% of adults globally, posing challenges due to its relapsing nature. Clarithromycin was used to treat the AD but failed due to low solubility and permeability on the target site. The present study aims to develop and evaluate the niosomal gel containing clarithromycin is used for the cure of atopic dermatitis. The niosomal suspension was optimized by using a design expert and the optimized formulation was characterized with the help of drug excipients compatibility, morphology, particle size, zeta potential, entrapment efficiency, drug loading, and in-vitro drug release which was found to be suitable for incorporation into the Carbopol-based gel to formulate CLR-N-Gel 0.1% w/w. The entrapment efficiency, drug loading, and cumulative drug release of niosomal suspension were found to be 86.17%, 23.16%, and 82.39% respectively. The suitable niosomal suspension was incorporated in carbopol-based gel and characterization has been done like physical appearance, pH, viscosity, spreadability, drug content, and in-vitro drug release of prepared CLR-N-Gel. The drug content of CLR-N-Gel was found to be 96 ? 2.16 %, cumulative drug release was found to be 80.74 %, and cumulative drug permeability was found to be 77.20%. The in-vivo anti-dermatitis efficacy and histopathology were carried out to check the efficacy of prepared CLR-N-Gel 0.1% w/w and found that the developed CLR-N-Gel 0.1% w/w gel showed fast recovery and better therapeutic efficacy with low concentration better skin permeation and prolonged drug release.
Keywords: Atopic dermatitis, clarithromycin, Optimization, nanoparticles, niosomal gel
How to Cite?: Ranjit Kumar Mahato, Md. Asad Quasim, "Development and Assessment of Nanoparticles: A Clarithromycin Niosomal Gel for Atopic Dermatitis", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 60-68, https://www.ijsr.net/getabstract.php?paperid=SR26209233318, DOI: https://dx.dx.doi.org/10.21275/SR26209233318