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Research Paper | Obstetrics and Gynecology | Volume 15 Issue 1, January 2026 | Pages: 1734 - 1739 | India
Hormonal Predictors of ICSI: AMH Versus FSH
Abstract: Background: Assessment of ovarian reserve is central to counselling and outcome prediction in IVF and ICSI cycles. Basal follicle-stimulating hormone (FSH) and anti-M?llerian hormone (AMH) are widely used markers, yet their relative ability to predict clinically meaningful outcomes such as live birth remains uncertain, particularly across different maternal age groups and in women with discordant hormonal profiles. Aim: To evaluate the association of basal Anti-M?llerian Hormone and Follicle-Stimulating Hormone levels with ovarian response and reproductive outcomes in women undergoing ICSI. Methods: This retrospective observational study included 127 women who underwent ICSI at Madras Medical Mission from 2020 to 2025. Participants were classified into four groups based on combined basal AMH and FSH levels like Group 1: AMH > 1 ng/mL and FSH ≤ 10 IU/mL, Group 2: AMH ≤ 1 ng/mL and FSH > 10 IU/mL, Group 3: AMH > 1 ng/mL and FSH > 10 IU/mL and Group 4: AMH ≤ 1 ng/mL and FSH ≤ 10 IU/mL. Maternal age was stratified into Group A (<35 years), Group B (35-37 years), Group C (37-40 years), and Group D (>40 years). Primary outcome was live birth rate. Secondary outcomes included antral follicle count, oocyte yield, number of mature (M2) oocytes, and clinical pregnancy rate. Group comparisons and regression analyses were performed to assess associations between hormonal markers and outcomes. Results: Women with concordantly favourable AMH and FSH levels demonstrated the highest antral follicle count, oocyte yield, and live birth rate. Significant differences were observed in oocyte yield, M2 oocytes, and live birth rate across AMH/FSH groups. Clinical pregnancy rates were higher in group with concordantly favourable AMH and FSH levels and lower in group with concordantly unfavourable AMH and FSH levels but did not differ significantly. In women younger than 35 years, multivariate analysis showed favourable basal FSH to be an independent predictor of live birth, while AMH and oocyte yield were not significant after adjustment. In women with discordant AMH and FSH profiles, AMH showed a stronger association with live birth than FSH. Conclusion: Basal FSH appears to be better predictor of live birth rate in women younger than 35 years, whereas AMH is a better predictor in women older than 35 years and with discordant hormonal profiles. Combined interpretation of AMH, FSH, and age provides a more clinically useful framework for prognostication in ICSI cycles.
Keywords: Anti-Mullerian hormone, Follicle-stimulating hormone, IVF, ICSI, Live birth rate, Ovarian reserve, Maternal age
How to Cite?: Dr. Haritha Kannan, Dr. Kundavi Shankar, Dr. Rashmi, Dr. Geetha, Dr. Geovin Ranji, "Hormonal Predictors of ICSI: AMH Versus FSH", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1734-1739, https://www.ijsr.net/getabstract.php?paperid=SR26129153220, DOI: https://dx.dx.doi.org/10.21275/SR26129153220