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India | Nutrition Science | Volume 15 Issue 1, January 2026 | Pages: 1161 - 1164
Exploring the Role of NAD+ in Cellular Metabolism, Aging, and Skin Rejuvenation: A Cosmetological Perspective
Abstract: Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme required for DNA repair, energy synthesis, and cellular metabolism. Its essential function in skin health, age modulation, and rejuvenation therapies has been demonstrated by recent developments in dermatological and cosmetological sciences. Age and environmental stress cause NAD+ levels to gradually drop, which results in decreased collagen synthesis, diminished mitochondrial function, and noticeable skin aging (Verdin, 2015). The biochemical relevance of NAD+, its molecular pathways affecting skin physiology, and its new uses in cosmetic and regenerative cosmetology are all examined in this research. The study emphasizes the significant role of NAD+ restoration techniques-such as topical NAD+ formulations, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) supplementation-in boosting skin healing, firmness, and brightness through an in-depth scientific analysis. The results substantiate the implementation of NAD+-enhancing treatments as a potential development in contemporary cosmetic procedures. Nicotinamide Adenine Dinucleotide (NAD+) is a key chemical in aging biology and aesthetic dermatology as it is an essential coenzyme involved in mitochondrial energy production, cellular repair, and genomic integrity. Skin aging and cellular senescence are accelerated by age-related declines in NAD+, which also contribute to diminished sirtuin activity, poor oxidative metabolism, and hampered DNA repair (Verdin, 2015). According to research, NAD+ depletion reduces fibroblast activity and extracellular matrix integrity, which are important causes of wrinkles, laxity, and pigmentation. It also increases oxidative stress and alters mitochondrial function (Poljsak & Milisav, 2016). Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) supplements increase cellular NAD+ pools, which improve skin resilience, restore metabolic efficiency, and encourage collagen formation (Rajman et al., 2018; Yoshino et al., 2018). Niacin derivatives' involvement in skin barrier repair, inflammatory control, and photoprotection is further highlighted by dermatological and nutritional research, which support their incorporation into cosmetology (Bogan & Brenner, 2008). According to recent research, NAD+ is particularly potential for skin renewal, repair responses, and recovery after aesthetic procedure (Knutson et al., 2020). With everything considered, NAD+ restoration offers therapeutic potential for anti-aging, regenerative skin care, and increased cellular vitality, making it a scientifically supported approach in contemporary cosmetology.
Keywords: NAD+, Skin Aging, Cosmetology, DNA Repair, Mitochondrial Health, Nicotinamide Riboside, Anti-Aging
How to Cite?: Dr. Bhakti Shashikant Unecha, "Exploring the Role of NAD+ in Cellular Metabolism, Aging, and Skin Rejuvenation: A Cosmetological Perspective", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1161-1164, https://www.ijsr.net/getabstract.php?paperid=SR26117172031, DOI: https://dx.doi.org/10.21275/SR26117172031