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Case Studies | Genetics | Volume 15 Issue 1, January 2026 | Pages: 1075 - 1079 | Indonesia
Diagnostic Approach and Management of Severe Hypokalemia in a Suspected Case of Bartter Syndrome: A Clinical Case Study
Abstract: Severe and life-threatening hypokalemia is defined as a plasma potassium level of <2.5 mEq/L. Hypokalemia can result from various factors, one of which is excessive potassium loss via the gastrointestinal tract, kidneys, or sweat. Bartter syndrome is a rare genetic disorder marked by impaired potassium reabsorption in the thick ascending limb of the loop of Henle, with an estimated prevalence of 1 in 1,000,000. This case study discusses the clinical presentation, diagnostic workup, and management of a 53-year-old male with severe hypokalemia (1.4 mEq/L) and suspected Bartter syndrome. The patient exhibited acute limb weakness without gastrointestinal or renal history and was evaluated with ECG, serum electrolytes, and transtubular potassium gradient, revealing renal potassium loss. Treatment involved IV and oral potassium supplementation, spironolactone, and dietary support. Diagnosis was based on clinical patterns and lab markers consistent with Bartter syndrome, although genetic testing was unavailable. The case underscores the importance of prompt identification and management of underlying renal causes of hypokalemia in emergency settings. This case report is intended to raise awareness and enhance clinical knowledge among physicians, enabling timely and appropriate management to reduce complications and improve the quality of life of patients with Bartter syndrome.
Keywords: Hypokalemia, Bartter Syndrome, potassium reabsorption, renal tubular disorder
How to Cite?: Roy Boris, Patriotika Ismail, "Diagnostic Approach and Management of Severe Hypokalemia in a Suspected Case of Bartter Syndrome: A Clinical Case Study", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1075-1079, https://www.ijsr.net/getabstract.php?paperid=SR26116191419, DOI: https://dx.dx.doi.org/10.21275/SR26116191419