Unlocking Fetal Potential: A Randomized Trial Exploring Levothyroxine?s Impact on Cognitive Outcomes in Subclinical Thyroid Dysfunction During Pregnancy
Abstract: Background: Subclinical thyroid dysfunction during pregnancy, encompassing subclinical hypothyroidism and hypothyroxinemia, has been linked to potential adverse neurodevelopmental outcomes in offspring, including impaired cognitive function. The impact of levothyroxine supplementation on cognitive outcomes in children of affected mothers remains uncertain. Methods: At Janm IVF & Fertility Centre in Tatarpur, Bhagalpur, between 2021 and 2024, pregnant women with singleton pregnancies were screened before 20 weeks of gestation in a randomized controlled trial. Subclinical hypothyroidism was defined as a thyrotropin (TSH) level ≥4.50 mU/L with a normal free thyroxine (T4) level (0.80-1.85 ng/dL [10-24 pmol/L]). Hypothyroxinemia was defined as a normal TSH level (0.10-4.00 mU/L) with a low free T4 level (
Keywords: Subclinical hypothyroidism, hypothyroxinemia, pregnancy, levothyroxine, neurodevelopmental outcomes, controlled trial, thyroid function
How to Cite?: Emrana Rahman, M Kamran Khan, "Unlocking Fetal Potential: A Randomized Trial Exploring Levothyroxine?s Impact on Cognitive Outcomes in Subclinical Thyroid Dysfunction During Pregnancy", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 1506-1512, https://www.ijsr.net/getabstract.php?paperid=SR25927151651, DOI: https://dx.doi.org/10.21275/SR25927151651