Prevalence and Antimicrobial Resistance of ESBL-Producing Gram - Negative Bacilli in Urinary Tract Infections at Red Sea Teaching Hospitals, Sudan
Abstract: Urinary tract infections (UTIs) remain among the most prevalent bacterial infections worldwide, particularly in resource-limited settings where empirical treatment is commonly practiced. This study aimed to determine the prevalence and antimicrobial susceptibility of extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacilli among symptomatic UTI patients at Port Sudan Teaching Hospitals. A cross-sectional study was conducted between January 2023 and January 2024, involving 150 patients with UTI symptoms. Midstream urine samples were cultured and tested for antimicrobial resistance using the Kirby-Bauer disk diffusion method. Of the 150 samples, 71 (47.3%) were culture-positive, with Escherichia coli as the most common isolate (20%). High resistance was noted against Ceftazidime (70%) and Nalidixic acid (60%), while Amikacin (64.7%) and Nitrofurantoin (56.9%) exhibited higher sensitivity. ESBL activity was phenotypically confirmed in 8 out of 34 resistant isolates. These findings underscore the urgent need for regular surveillance and informed antibiotic prescribing to curb resistance in the region.
Keywords: Urinary tract infection, antimicrobial resistance, ESBL, Gram-negative bacilli, Sudan
How to Cite?: Osman Hashim Shingrai Eissa, Mohamed AboHoussien, Elamin Ibrahim, "Prevalence and Antimicrobial Resistance of ESBL-Producing Gram - Negative Bacilli in Urinary Tract Infections at Red Sea Teaching Hospitals, Sudan", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 439-442, https://www.ijsr.net/getabstract.php?paperid=SR25909001724, DOI: https://dx.doi.org/10.21275/SR25909001724