Association Between Helicobacter Pylori Infection and Glycemic Control in Type 2 Diabetes Mellitus Patients with Dyspepsia: A Clinicopathological Study

Dr. Priyam Srivastava, Dr. Anubha Srivastava, Dr. Sandeep Kumar Prajapathi

Abstract: Background: Type 2 Diabetes Mellitus (T2DM) is associated with gastrointestinal disturbances, including dyspepsia. Chronic Helicobacter pylori (H. pylori) infection may exacerbate these symptoms and potentially influence glycemic control. This study investigates the relationship between H. pylori infection and glycemic control in dyspeptic T2DM patients, using rapid urease test (RUT), histopathology, and upper gastrointestinal endoscopy. Methods: A cross-sectional analytical study was conducted on 114 T2DM patients aged 35?60 years presenting with dyspepsia. All patients underwent upper GI endoscopy, gastric biopsy for histopathology, and RUT for H. pylori detection. Glycemic control was assessed via HbA1c levels. Statistical analysis included comparison of HbA1c values between H. pylori-positive and negative groups, and correlation with endoscopic and histological findings. Results: Of the 114 patients, 75 (65.8%) tested positive for H. pylori on RUT, and 70 (61.4%) were confirmed by histopathology. The mean HbA1c in H. pylori-positive patients was significantly higher (8.5%) compared to H. pylori-negative individuals (7.4%) (p = 0.005). Endoscopic findings such as erythema, nodularity, and erosions were more frequent in the H. pylori-positive group. Histopathological examination revealed chronic active gastritis in the majority of infected individuals. Conclusion: H. pylori infection is common in T2DM patients with dyspepsia and is significantly associated with poorer glycemic control. Screening and treatment of H. pylori infection in diabetics may improve both gastrointestinal symptoms and metabolic outcomes.

Keywords: Helicobacter pylori, Type 2 Diabetes Mellitus, Glycemic Control, HbA1c, Dyspepsia, Rapid Urease Test, Endoscopy, Histopathology

How to Cite?: Dr. Priyam Srivastava, Dr. Anubha Srivastava, Dr. Sandeep Kumar Prajapathi, "Association Between Helicobacter Pylori Infection and Glycemic Control in Type 2 Diabetes Mellitus Patients with Dyspepsia: A Clinicopathological Study", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1641-1643, https://www.ijsr.net/getabstract.php?paperid=SR25826205024, DOI: https://dx.doi.org/10.21275/SR25826205024