Retrospective Observational Study for Statin Induced Hyperglycaemia in Drug Naive Pre Diabetes Population

Md Kamran Khan, Firdous Shaikh

Abstract: Aim: The aim of the present study to explore the possible flare of hyperglycaemia and onset of Diabetes in drug na?ve prediabetes population by using higher dose of statins for dyslipidaemia. Material & Methods: It was a retrospective observational study done at Nidan Kutir Diabetes Care, Bhagalpur, Bihar from the period of March 2023- to February 2024. Written consent was taken from all the patients with prediabetes. A total of 230 patients were included in the study, with male to female ratio being 60/40% respectively, aged 27 years to 47 years, mean age being 38 years. Of 230 patients, 32 patients failed to complete the study. Helsinki protocols were kept in mind for this study. Results: Of all patients completed the study period male were nearly more than half in numbers whereas females constituted 10 patients with post-menopausal state. The mean age group was 38 years. Dyslipidaemia was associated with 84% patients, Hypertension was present in 32% patients, history of coronary artery disease or ASCVD in 17% of the study population. A total of 42% patients received ACEIs/ARBs/BB as adjunct medications beside anti platelet agents like aspirin and clopidogrel in 20% of the patients. Statins like atorvastatin, rosuvastatin and pitavastatin which are HMG-CoA inhibitors in different strength were administered during the study period. Atorvastatin 20 mg was most frequently prescribed statin (92) followed by atorvastatin 40 mg (58), Rosuvastatin 20 (22), Rosuvastatin 40 (18) and Pitavastatin 4 mg (08) HOMA-IR and Fasting C- Peptide were done to identify insulin resistance in suspected patients, and HbA1c value measured in all patients. All patients who developed NODM (New Onset Diabetes Mellitus) after having higher dose of statins had HbA1c value more than 6.5% with FBS> 126, AND PPBG more than 200 mg/dl. Conclusion: Statins carry a mild-to-moderate risk of new-onset diabetes mellitus (NODM), with higher doses significantly increasing this risk in statin users.

Keywords: Hyperglycaemia, new onset diabetes (NODM), statins, Dyslipidaemia

How to Cite?: Md Kamran Khan, Firdous Shaikh, "Retrospective Observational Study for Statin Induced Hyperglycaemia in Drug Naive Pre Diabetes Population", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1356-1359, https://www.ijsr.net/getabstract.php?paperid=SR25824152355, DOI: https://dx.doi.org/10.21275/SR25824152355