Pancreatitis in a Young Adult on Valproate: A Rare but Serious Adverse Effect

Amit Kumar, Sandeep Garg, Praveen Bharti, Bhvika Zutshi, Ved Prakash Yadav, Shweta Ambedare

Abstract: Valproic acid (VPA) is a commonly prescribed antiepileptic drug with a favorable safety profile. However, rare but serious adverse effects like acute pancreatitis have been reported, particularly in children and young adults. We describe a 19-year-old male with generalized tonic-clonic seizures on sodium valproate monotherapy who presented with acute epigastric pain, vomiting, and absent bowel movements. Laboratory tests showed markedly elevated serum amylase and lipase. Imaging confirmed acute interstitial pancreatitis. Common etiologies, including alcohol use, gallstones, hypertriglyceridemia, and infection, were excluded. Given the temporal association and resolution following drug withdrawal, a diagnosis of valproate-induced pancreatitis (VIP) was made, supported by a Naranjo score of 6. Valproate was discontinued, supportive care initiated, and levetiracetam introduced for seizure control. The patient showed clinical improvement within 72 hours and remained recurrence-free on follow-up. This case highlights the importance of considering VIP in young patients presenting with pancreatitis of unclear etiology.

Keywords: Valproate, Acute Pancreatitis, Drug-Induced Pancreatitis, Antiepileptic Drug Toxicity, Case Report

How to Cite?: Amit Kumar, Sandeep Garg, Praveen Bharti, Bhvika Zutshi, Ved Prakash Yadav, Shweta Ambedare, "Pancreatitis in a Young Adult on Valproate: A Rare but Serious Adverse Effect", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1109-1111, https://www.ijsr.net/getabstract.php?paperid=SR25819191531, DOI: https://dx.doi.org/10.21275/SR25819191531