Gastrointestinal Disseminated Histoplasmosis Masquerading as Sigmoid Colon Cancer in an Immunocompromised Patient

Nathan Jatczak, Joey Marcuccilli, John Hiscock, Evan Nuels

Abstract: Disseminated histoplasmosis is a rare fungal infection that may mimic colorectal malignancy, especially in immunocompromised individuals. We present the case of a 74-year-old male with multiple myeloma who developed near-obstructive sigmoid colon lesions initially suspected to be malignant. Histopathology confirmed Histoplasma capsulatum infection. Despite amphotericin B followed by itraconazole, the patient?s condition progressed to complete obstruction, necessitating colectomy. This report underscores the diagnostic challenge of gastrointestinal histoplasmosis, the limitations of antifungal therapy in advanced lesions, and the importance of considering surgical intervention when medical management fails.

Keywords: Histoplasmosis, Gastrointestinal Infection, Sigmoid Colon, Immunocompromised Patient, Colectomy

How to Cite?: Nathan Jatczak, Joey Marcuccilli, John Hiscock, Evan Nuels, "Gastrointestinal Disseminated Histoplasmosis Masquerading as Sigmoid Colon Cancer in an Immunocompromised Patient", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 665-668, https://www.ijsr.net/getabstract.php?paperid=SR25813015419, DOI: https://dx.doi.org/10.21275/SR25813015419