ASL in the Aging Mind: Tracing Perfusion Patterns in Emerging Dementia

Dr. Malgireddy Vinitha, Dr. Uma Maheshwara Reddy, Dr. Rama Krishna Rao Baru, Dr. Pentyala Suneetha

Abstract: Arterial Spin Labeling (ASL) is a novel, non-invasive MRI-based perfusion imaging technique utilizing magnetically labelled arterial blood as an endogenous tracer to quantify cerebral blood flow (CBF). Dementia, a clinical syndrome defined by progressive decline in one or more cognitive domains, is a growing global health challenge, presents with characteristic regional perfusion deficits corresponding to specific neurodegenerative pathologies. ASL enables early detection of such patterns, aiding in the diagnosis and differentiation of dementia subtypes, including Alzheimer's disease (AD), Frontotemporal Dementia (FTD), and Dementia with Lewy Bodies (DLB). This paper outlines the clinical application of ASL in detecting early perfusion changes in patients with cognitive decline and discusses imaging correlations in typical dementia cases.

Keywords: ASL, dementia, MRI, perfusion patterns, cognitive decline, Alzheimer?s disease, Fronto-temporal dementia, Lewy body dementia

How to Cite?: Dr. Malgireddy Vinitha, Dr. Uma Maheshwara Reddy, Dr. Rama Krishna Rao Baru, Dr. Pentyala Suneetha, "ASL in the Aging Mind: Tracing Perfusion Patterns in Emerging Dementia", Volume 14 Issue 6, June 2025, International Journal of Science and Research (IJSR), Pages: 1340-1342, https://www.ijsr.net/getabstract.php?paperid=SR25618104216, DOI: https://dx.doi.org/10.21275/SR25618104216