Study of serum Vitamin B12 and its association with Lipid profile in Type 2 Diabetes Mellitus

Sukhpreet Kaur

Abstract: Diabetes Mellitus stands as a significant global health concern and is recognized as a leading cause of mortality worldwide. Its associated complications, including peripheral neuropathy, nephropathy, retinopathy, coronary artery disease, and cerebrovascular disease, contribute significantly to the morbidity and mortality rates associated with the condition. Vitamin B12, a water-soluble vitamin, plays a crucial role in the physiological processes related to the methylation of the myelin sheath. Deficiency in Vitamin B12 can disrupt this methylation process, leading to the accumulation of intracellular and serum homocysteine. Elevated homocysteine levels are recognized as potentially toxic to both neurones and vascular endothelium. The present study aims to assess and compare the levels of serum Vitamin B12 in individuals diagnosed with type 2 diabetes mellitus against a control group. This comparative analysis seeks to shed light on potential variations in Vitamin B12 levels in individuals with diabetes, offering insights into its role in the context of diabetes-related complications. Furthermore, the study seeks to establish correlations between serum Vitamin B12 levels and the lipid profile of individuals with type 2 diabetes mellitus. Understanding the interplay between Vitamin B12 and lipid metabolism may provide valuable information for the management and prevention of complications associated with diabetes. By exploring these relationships, the study aspires to contribute to the existing body of knowledge regarding the complex interconnections between Vitamin B12 status, diabetes mellitus, and associated complications. The findings may have implications for the development of targeted interventions and treatment strategies aimed at mitigating the impact of diabetes-related complications. All the parameters, FBS, HbA1, cholesterol, triglyceride levels were found to be increased in the patients of Type 2 Diabetes Mellitus as compared to controls except Vitamin B12 and HDL. The correlation of mean serum Vitamin B12 levels with other parameters was significant. From the present study, it is concluded that there is decrease in serum vitamin B12 Level with increase HBA1C, cholesterol and triglycerides levels.

Keywords: Diabetes Mellitus, Glycated Hemoglobin, Fasting Blood Sugar, Impaired Glucose Tolerance, Impaired Fasting Glycemia, Gestational Diabetes Mellitus, High Density Lipoprotein Post- Prandial Blood Sugar Very Low Density Lipoprotein Diphosphopyridine Neuclotide

How to Cite?: Sukhpreet Kaur, "Study of serum Vitamin B12 and its association with Lipid profile in Type 2 Diabetes Mellitus", Volume 14 Issue 6, June 2025, International Journal of Science and Research (IJSR), Pages: 864-867, https://www.ijsr.net/getabstract.php?paperid=SR25604200014, DOI: https://dx.doi.org/10.21275/SR25604200014