Cholesterol-Induced Toxicity and its Dietary Links Multiple Disease: Prospective Overview

Dr. Shaik Salma, G. Sangeetha, B. Priya Chandana Spurthi, M. Guru Bhavitha, C. Supraja, Dr S. Nivedhitha

Abstract: The study aims to examine the toxicological effect of dietary cholesterol and its role in the progression of multiple diseases, with particular attention to gender differences and food sources. Cholesterol plays a significant role in multiple diseases, particularly cardiovascular diseases (CVD), where elevated low - density lipoprotein (LDL) cholesterol is strongly linked to atherosclerosis and heart disease risk. Lifelong elevated LDL cholesterol is a well - established risk factor for CVD, supported by extensive genetic, clinical trial, and epidemiological evidence9. Beyond cardiovascular effects, cholesterol and its oxidized forms often generated by high - heat cooking methods may contribute such as frying or grilling - may contribute to toxicity and disease progression by promoting oxidative stress and inflammation. Dietary cholesterol from foods can influence blood cholesterol levels, but the impact varies depending on the type of cholesterol consumed and how food is prepared. Oxidized cholesterol, formed in processed or fried foods, is particularly implicated in adverse health effects. Cholesterol - induced toxicity can affect multiple organs and systems, contributing to diseases like liver toxicity and metabolic disorders, often through mechanisms involving oxidative stress and inflammation. In my view, the study offers a compelling overview of how elevated level of low - density lipoprotein (LDL) and oxidized cholesterol _particularly from processed and high heat - cooked foods - contribute to toxicity and chronic diseases. It is evident that cholesterol induced oxdative stress and inflammation are central to the development of cardiovascular, liver and metabolic disorders. This suggests that dietary habits play a key role in cholesterol regulation and disease prevention. The manage cholesterol intake through conscious food choices and preparation method to mitigate health risks. In summary, cholesterol, especially elevated LDL and oxidized cholesterol from certain foods, plays a critical role in the prevalence and progression of multiple diseases, primarily cardiovascular disease, but also liver and metabolic toxicities. Managing cholesterol intake and food preparation methods can help mitigate these risks. A clearer understanding of cholesterol is dietary pathways and disease linkages can support targeted public health interventions and guide nutritional education programs.

Keywords: Cholesterol toxicity, LDL cholesterol, dietary fats, chronic disease, cardiovascular health

How to Cite?: Dr. Shaik Salma, G. Sangeetha, B. Priya Chandana Spurthi, M. Guru Bhavitha, C. Supraja, Dr S. Nivedhitha, "Cholesterol-Induced Toxicity and its Dietary Links Multiple Disease: Prospective Overview", Volume 14 Issue 6, June 2025, International Journal of Science and Research (IJSR), Pages: 578-596, https://www.ijsr.net/getabstract.php?paperid=SR25601220811, DOI: https://dx.doi.org/10.21275/SR25601220811