Understanding Wunderlich Syndrome: Causes, Diagnosis, and Challenges

Dr. Amrit Adisht, Dr. Amritpreet Singh, Dr. Sarfaraz Shaikh, Dr. Madan Manmohan

Abstract: Wunderlich syndrome (WS), which was named after Carl Wunderlich, is a rare clinical syndrome characterized by an acute onset of spontaneous renal hemorrhage into the subcapsular, perirenal, and/or pararenal spaces, without a history of antecedent trauma. Patients may present with a multitude of symptoms ranging from nonspecific flank or abdominal pain to serious manifestations such as hypovolemic shock. The classic symptom complex of flank pain, a flank mass, and hypovolemic shock referred to as the Lenk triad is seen in a small subset of patients. Rare causes of WS include renal infections, cystic diseases, calculi, kidney failure, and coagulation disorders. Cross-sectional imaging modalities, particularly multiphasic CT or MRI, are integral to the detection, localization, and characterization of the underlying causes and facilitate optimal management.

Keywords: Wunderlich, rare, spontaneous renal hemorrhage, flank mass, hypovolemic shock, Lenk triad