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Analysis Study Research Paper | Cardiology Science | India | Volume 14 Issue 3, March 2025 | Popularity: 5.4 / 10
Elevated Admission Total Leukocyte Count in Young Patients with Coronary Artery Disease: A Potential Marker of Inflammation and Cardiovascular Risk
Dr. Vinay Pandey, Dr. Akash Gupta, Dr. Piyush Saxena
Abstract: Background: Coronary artery disease (CAD) in young individuals is increasingly recognized as a major health concern. Inflammation plays a pivotal role in the pathogenesis of CAD, and Total Leukocyte Count (TLC) has been suggested as a potential biomarker of inflammatory burden. This study aims to evaluate the relationship between elevated TLC and CAD in young patients, assessing its potential as a predictive marker of cardiovascular risk. Methodology: This cross - sectional observational study was conducted at Swaroop Rani Nehru Hospital, Prayagraj, involving patients aged 18 - 45 years presenting with chest pain and subsequently diagnosed with CAD. Clinical history, physical examination, and laboratory investigations, including elevated admission TLC levels, were recorded. Patients were categorized into two groups based on elevated admission TLC levels: elevated admission TLC (?10, 000/mm?) and Normal TLC (<10, 000/mm?). The association between TLC levels and demographic, clinical, and biochemical parameters was analyzed using Pearson?s Chi - Square test, with a significance level set at p<0.05. Results: Among the 100 patients enrolled, the majority (71.7%) were aged 41 - 45 years. Elevated TLC was significantly more common in males (78.3%) than females (21.7%). Clinical symptoms such as chest pain (100%), diaphoresis (93.3%), nausea/vomiting (60%), and smoking history (63.3%) were more prevalent in patients with increased TLC. The statistical analysis revealed a significant association between elevated admission TLC and mortality, with a p - value of 0.012, suggesting that higher TLC levels may indicate a higher inflammatory burden contributing to adverse cardiovascular outcomes. Conclusion: Elevated admission TLC in young CAD patients is strongly associated with increased inflammatory burden and adverse clinical outcomes. These findings highlight the potential role of TLC as a simple, cost - effective inflammatory biomarker for early risk stratification and prognosis in young CAD patients. Further studies are required to validate its predictive utility in clinical practice.
Keywords: Coronary artery disease, Total Leukocyte Count, Inflammation, Young CAD, Biomarkers, Cardiovascular risk
Edition: Volume 14 Issue 3, March 2025
Pages: 1174 - 1177
DOI: https://www.doi.org/10.21275/SR25323144854
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