Male Irritable Syndrome: A Comprehensive Review of Andropause and Hormonal Influences

Dr. Venugopal Reddy I.

Abstract: Male Irritable Syndrome (MIS), also known as Irritable Male Syndrome (IMS), arises from hormonal shifts, notably testosterone decline during andropause, leading to emotional, physical, and cognitive disturbances that profoundly affect quality of life. This review delves into the clinical features, risk factors, and epidemiology of MIS, alongside its intricate pathophysiology involving neurotransmitter imbalances and inflammation. It outlines diagnostic challenges, integrative management options like testosterone therapy and lifestyle modifications, and underscores the relevance of early awareness in pediatric care to prevent later severity. Despite its growing prevalence, MIS remains underrecognized, necessitating improved clinician education and targeted research into biomarkers and personalized treatments to enhance patient outcomes.

Keywords: Male Irritable Syndrome, Testosterone, Andropause, Mood Disorders, Hormone Replacement Therapy