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Comparative Studies | Anaesthesiology | India | Volume 14 Issue 3, March 2025 | Popularity: 5.8 / 10
Evaluation of Role of Nebulized Magnesium Sulphate on the Incidence of Sore Throat in Patients Intubated with Cuffed Endotracheal Tube - A Prospective Double Blinded Study
Dr. Jesmin Patel, Dr. Dhruti prasad Parida
Abstract: Background and aims: Postoperative sore throat (POST) is a well - recognized complication after general anaesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success. The present study was conducted to compare the efficiency of preoperative nebulization of magnesium sulphate and normal saline in reducing the incidence of POST, POC (post operative cough), POH (post operative hoarseness of voice) following GA. Study design: This study was a prospective randomized, double - blinded study. Materials and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double blinded study was conducted in 100 cases divided in to two equal groups. Patients included in the study were of either gender belonging to American Society of Anaesthesiologist (ASA) status 1 or 2 undergoing elective surgery for less than 2 hours duration requiring tracheal intubation. Patients in Group 1 were nebulized with 3ml solution containing 250 mg of magnesium sulphate and Group 2 were nebulized with 3ml of normal saline for 15 mins, 5 mins before induction of anaesthesia. The incidence Post operative sore throat (POST), post operative cough (POC), post operative hoarseness of voice (POH) were evaluated at 0, 4, 8, 12, 24 hours in the post operative period. Results and discussion: The findings of this study showed that preoperative nebulization with magnesium sulfate had decreased the incidence of sore throat compared to the control group at 0hrs (p<0.002759); at 4hrs (p<0.00001); 8hrs (p<0.00001); 12hrs (p<0.00001) and at 24hrs (p<0.00001). There was significant reduction in POC at 0hr (p=0.009244) after nebulization with magnesium sulfate than in the normal saline group. The incidence of hoarseness was significantly reduced with the use of magnesium sulfate compared to normal saline at 8th hours. Conclusion: Preoperative magnesium sulfate nebulization is considered to be effective in reducing post operative sore throat compared to normal saline. Magnesium sulfate nebulization in the pre operative period has reduced the incidence of post operative cough at 0hrs and post operative hoarseness at 8hrs.
Keywords: Magnesium sulphate, Nebulization, Post operative sore throat, Post operative cough, Post operative hoarseness of voice
Edition: Volume 14 Issue 3, March 2025
Pages: 384 - 388
DOI: https://www.doi.org/10.21275/SR25307104252
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