Left Ventricular Diastolic Dysfunction in Chronic Liver Disease: Prevalence, Clinical Correlation, and Prognostic Significance

Anbu Krithigha Dharmalingam, Ganesh P, Shanmuganathan S, A K Koushik, Sai Dheeraj Mulpuri, Samir Jaju

Abstract: Left ventricular diastolic dysfunction (LVDD) in chronic liver disease patients results from splanchnic vasodilation, triggering the renin-angiotensin-aldosterone system and creating a hyperdynamic state. This condition can lead to increased risk of hepatorenal syndrome and poor prognosis. This study aims to determine the prevalence of LVDD in chronic liver disease patients at a tertiary care centre and to correlate its grades with clinical parameters and prognostic markers. In this observational study of 83 patients, LVDD was found in 76% of cases, with grades I, II and III occurring in 65 %, 28.6% and 6.4 % of patients, respectively. Higher-grade LVDD was associated with complications such as acute kidney injury, hepatic encephalopathy, and higher CTP and MELD-Sodium scores. These findings emphasize the need for early cardiac evaluation in chronic liver disease patients to mitigate adverse outcomes.

Keywords: Diastolic dysfunction in cirrhosis, Left Ventricular dysfunction, chronic liver disease, cirrhosis, echocardiography, prognosis