Neuroprotective Effects of Centella asiatica in the Management of Epilepsy

Kanchi Siva Prasad, Meesala Guru Sekhar

Abstract: Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal excitability and synchronization. Despite the availability of several antiepileptic drugs, long-term therapy is often associated with adverse effects and incomplete seizure control, necessitating the exploration of safer and more effective alternatives. Centella asiatica, a well-known medicinal plant used in traditional systems of medicine, has gained considerable attention for its neuroprotective and cognitive-enhancing properties. This study investigates the neuroprotective role of Centella asiatica in managing epilepsy using a pentylenetetrazole (PTZ)-induced seizure model in Wistar rats. The methanol extract of the plant was evaluated for its influence on oxidative stress markers, specifically superoxide dismutase (SOD) and catalase (CAT), across various brain regions. Rats pre-treated with C. asiatica extract demonstrated a significant increase in antioxidant enzyme activities compared to the PTZ-only group, indicating reduced oxidative damage. The results suggest that C. asiatica may offer neuroprotective benefits and serve as a complementary therapy in epilepsy management. However, further clinical studies are necessary to confirm its efficacy and safety in humans. Experimental studies suggest that Centella asiatica modulates neurotransmitter balance, reduces oxidative stress, stabilizes neuronal membranes and enhances ?-aminobutyric acid (GABA) activity, thereby suppressing seizure activity. Additionally, its ability to protect hippocampal neurons and improve synaptic plasticity may help prevent epilepsy-associated cognitive impairment. The plant also exhibits minimal toxicity, supporting its potential as an adjunct or alternative therapy. Although preclinical findings are promising, well-designed clinical trials are required to establish its efficacy, safety, dosage and mechanism of action in human epilepsy. Overall, Centella asiatica represents a promising neuroprotective herbal candidate for the management of epilepsy.

Keywords: Epilepsy, Centella asiatica, Neuroprotection, Antiepileptic activity, Antioxidant enzymes, Wistar rats

How to Cite?: Kanchi Siva Prasad, Meesala Guru Sekhar, "Neuroprotective Effects of Centella asiatica in the Management of Epilepsy", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 1048-1051, https://www.ijsr.net/getabstract.php?paperid=SR251213210901, DOI: https://dx.doi.org/10.21275/SR251213210901