Histomorphologic Study of Uterine and Cervical Lesion in Hysterectomy Specimen in the Department of Pathology and JA Groups of Hospitals, A Prospective Study

Dr. Meenakshi Patel, Dr. Reena Jain, Dr. Sudha Iyengar, Dr. Sonal Kulshreshtha

Abstract: Background: The female reproductive system is vulnerable to a wide range of benign and malignant disorders. Despite the availability of conservative therapies, hysterectomy remains one of the most commonly performed gynecological surgeries worldwide. Histopathological evaluation of hysterectomy specimens plays a crucial role in identifying underlying lesions, including occult malignancies. Aim: To analyze the histomorphological spectrum of uterine and cervical lesions in hysterectomy specimens and correlate them with age and clinical presentation. Materials and Methods: This prospective study was conducted in the Department of Pathology, JA Group of Hospitals, Gajra Raja Medical College, Gwalior, from May 2023 to October 2024. A total of 380 hysterectomy specimens fulfilling the inclusion criteria were examined. Following fixation, gross examination, tissue sampling, processing, and H&E staining, histopathological evaluation of uterine and cervical components was performed. Data were analyzed using IBM SPSS Statistics v20 and Jamovi v2.3.28. Results: The highest frequency of hysterectomy was observed in the 41?50-year age group (46.3%). Total hysterectomy with bilateral adnexal removal was the most common procedure (60%). In the endometrium, proliferative phase was the predominant pattern (44.7%), whereas premalignant and malignant lesions?including hyperplasia with atypia (5.3%), EIN (1.1%), and endometrial carcinoma (2.9%)?were also identified. In the myometrium, leiomyoma (26.6%) and adenomyosis (17.6%) were the most prevalent findings. Cervical evaluation revealed chronic non-specific cervicitis as the most common lesion (78.2%); however, CIN/CIS and invasive cervical carcinoma were detected in 6.3% of cases. Conclusion: Histopathological examination of hysterectomy specimens is imperative for detecting clinically significant premalignant and malignant lesions, particularly in perimenopausal women, and is fundamental to optimal diagnostic and therapeutic decision-making.

Keywords: Hysterectomy, Histomorphology, Uterine, Cervical lesions, Cervical intraepithelial neoplasia (CIN)

How to Cite?: Dr. Meenakshi Patel, Dr. Reena Jain, Dr. Sudha Iyengar, Dr. Sonal Kulshreshtha, "Histomorphologic Study of Uterine and Cervical Lesion in Hysterectomy Specimen in the Department of Pathology and JA Groups of Hospitals, A Prospective Study", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 766-770, https://www.ijsr.net/getabstract.php?paperid=SR251210133424, DOI: https://dx.doi.org/10.21275/SR251210133424