Synthesis, Characterization and Evaluation of Biological Activity of New Spirocyclic Pyrazolones
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Analysis Study Research Paper | Chemistry | India | Volume 14 Issue 1, January 2025 | Popularity: 5.3 / 10


     

Synthesis, Characterization and Evaluation of Biological Activity of New Spirocyclic Pyrazolones

Vipin Kumar Singh Vijay Pratap Singh, Amrendra Kumar Singh


Abstract: Stereoselective Michael- aldol sequential reaction is used for synthesis of carbocyclic six membered spiro Pyrazolones. The [(Z)-4-bromo-3-(4-chlorophenyl)but-2-enal] and [(E)-4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazole-3-one] were stirred in DCM in 20-mol % of catalyst (lb) and 20-mol % of O- fluoro benzoic acid, gives [(5S)-8-(4-chlorophenyl)-4-methyl-2, 10-diphenyl-2, 3-diazaspiro(4- 5)deca-3, 7-diene-1, 6-dione], with high range of diastereoselectivity and enantioselectivity (up to >20:1 dr and 99% ee ). The synthesized compound gives satisfactory results for 1H NMR, 13C NMR, IR spectra, and polarimeter. Antimicrobial by examinations shows all newly synthesized derivatives are active against bacteria (S. aureus, B. subtilis, P. aeruginosa and E. coli), and Fungi (A. niger).


Keywords: Stereoselective, ?-? unsaturated aldehyde, vinyl Pyrazolones, Antimicrobial agent, Carbocyclic


Edition: Volume 14 Issue 1, January 2025


Pages: 761 - 767


DOI: https://www.doi.org/10.21275/SR25117075828



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Vipin Kumar Singh Vijay Pratap Singh, Amrendra Kumar Singh, "Synthesis, Characterization and Evaluation of Biological Activity of New Spirocyclic Pyrazolones", International Journal of Science and Research (IJSR), Volume 14 Issue 1, January 2025, pp. 761-767, https://www.ijsr.net/getabstract.php?paperid=SR25117075828, DOI: https://www.doi.org/10.21275/SR25117075828