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Analysis Study Research Paper | Chemistry | Volume 14 Issue 1, January 2025 | Pages: 761 - 767 | India
Synthesis, Characterization and Evaluation of Biological Activity of New Spirocyclic Pyrazolones
Abstract: Stereoselective Michael- aldol sequential reaction is used for synthesis of carbocyclic six membered spiro Pyrazolones. The [(Z)-4-bromo-3-(4-chlorophenyl)but-2-enal] and [(E)-4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazole-3-one] were stirred in DCM in 20-mol % of catalyst (lb) and 20-mol % of O- fluoro benzoic acid, gives [(5S)-8-(4-chlorophenyl)-4-methyl-2, 10-diphenyl-2, 3-diazaspiro(4- 5)deca-3, 7-diene-1, 6-dione], with high range of diastereoselectivity and enantioselectivity (up to >20:1 dr and 99% ee ). The synthesized compound gives satisfactory results for 1H NMR, 13C NMR, IR spectra, and polarimeter. Antimicrobial by examinations shows all newly synthesized derivatives are active against bacteria (S. aureus, B. subtilis, P. aeruginosa and E. coli), and Fungi (A. niger).
Keywords: Stereoselective, ?-? unsaturated aldehyde, vinyl Pyrazolones, Antimicrobial agent, Carbocyclic
How to Cite?: Vipin Kumar Singh Vijay Pratap Singh, Amrendra Kumar Singh, "Synthesis, Characterization and Evaluation of Biological Activity of New Spirocyclic Pyrazolones", Volume 14 Issue 1, January 2025, International Journal of Science and Research (IJSR), Pages: 761-767, https://www.ijsr.net/getabstract.php?paperid=SR25117075828, DOI: https://dx.doi.org/10.21275/SR25117075828